Lipid nanoparticle delivery of siRNA to dorsal root ganglion neurons to treat pain
Xiangfei Han, Veselina Petrova, Yudong Song, Yu‐Ting Cheng, Xingya Jiang, Hui Hua Zhou, Caleb Hu, Dean Shuailin Chen, Hyo Jeong Yong, Hyoung Woo Kim, Biyao Zhang, Omer Barkai, Aakanksha Jain, William R. Renthal, Philipp B. Lirk, , Jinjun Shi
This study demonstrates the use of lipid nanoparticles to deliver siRNA to dorsal root ganglion neurons, effectively silencing TRPV1 and reducing pain-related behaviors.
bioRxiv · Jan 23, 2025 · PreprintNeuroscience