Non-Carbohydrate Inhibitors of Sialic Acid-binding Immunomodulatory-type Lectin-7 (Siglec-7) Discovered from Genetically Encoded Bicyclic Peptide Libraries
Danial Yazdan, A. Michael Downey, Ana Gimeno, Caishun Li, Edward N. Schmidt, Jeffrey Y. K. Wong, Caleb Loo, Jaesoo Jung, Ryan Qiu, Ewa T. Lis, Lily Lindmeier, June Ereño‐Orbea, Jesús Jiménez‐Barbero, Matthew Scott Macauley, Ratmir Derda
This paper discovers non-carbohydrate inhibitors of Siglec-7:GD3 interactions using BiGEL libraries and validates their potency through SPR, ELISA, and NMR.
Journal of the American Chemical Society · Sep 9, 2026Peer-reviewedBiochemistry