Protective IFIH1 variant reduces immune-mediated islet stress and dysfunction in a type 1 diabetes genetic background
Daniel Veronese-Paniagua, Cameron E Banks, Kameron Bradley, Noyonika Mukherjee, Sarah E. Gale, Kate E. Hinshaw, Amy M. Meacham, Opeoluwa F Iwaloye, Hubert Ming Tse, Clayton E. Mathews, Jeffrey R. Millman
This study shows that the IFIH1 E627* variant protects human pancreatic islets from stress-induced dysfunction by reducing immune responses and apoptosis.
bioRxiv · Dec 31, 2025 · PreprintCell Biology