Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Qunxiang Ong, Ler Ting Rachel Lim, Cameron Goh, Yilie Liao, Sher En Chan, Crystal Jing Yi Lim, Valerie Kam, Jerome Yap, Tiffany Tseng, Reina Desrouleaux, Loo Chien Wang, Siok Ghee Ler, Siew Lay Lim, Sun-Yee Kim, Radoslaw Mikolaj Sobota, , Xiaoyong Yang
This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.
Nature Chemical Biology · Nov 14, 2024Peer-reviewedCell Biology