Author

Siok Ghee Ler

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Loo Chien WangiD· 3 shared Radoslaw Mikolaj SobotaiD· 3 shared Crystal Jing Yi Lim· 2 shared Ler Ting Rachel LimiD· 2 shared Qunxiang OngiD· 2 shared Sher En Chan· 2 shared Weiping HaniD· 2 shared Yilie LiaoiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Loo Chien WangORCID

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3 papers

Recent·Most cited

Ovarian extracellular matrix mechanics regulate oocyte-follicle interactions during female reproductive aging

Xingyu Shen, Hao Wang, Gefei Cao, Yaelim Lee, Jin Zhu, Loo Chien Wang, Tianyun Zhao, Siok Ghee Ler, Radoslaw M. Sobota, Rong Li, Jennifer L. Young

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

Aging Cell · Aug 1, 2026Peer-reviewedCell Biology

Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution

Qunxiang Ong, Crystal Jing Yi Lim, Yilie Liao, Justin Tze-Yang Ng, Ler Ting Rachel Lim, Shernys Xuan Yi Koh, Sher En Chan, P Lee, Hui-Jun Lim, Chen Ye, Loo Chien Wang, Siok Ghee Ler, Radoslaw Mikolaj Sobota, Yaw Sing Tan, Gerald I. Shulman, , Weiping Han

This paper develops an optogenetic tool to control PKC epsilon activity with spatiotemporal precision and validates its function in phosphorylation events.

bioRxiv · Jan 6, 2025 · PreprintMolecular Biology

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

Qunxiang Ong, Ler Ting Rachel Lim, Cameron Goh, Yilie Liao, Sher En Chan, Crystal Jing Yi Lim, Valerie Kam, Jerome Yap, Tiffany Tseng, Reina Desrouleaux, Loo Chien Wang, Siok Ghee Ler, Siew Lay Lim, Sun-Yee Kim, Radoslaw Mikolaj Sobota, , Xiaoyong Yang

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

Nature Chemical Biology · Nov 14, 2024Peer-reviewedCell Biology