Radoslaw Mikolaj Sobota

This study investigates how Ara h 2 and FcϵRI binding affect IgE structural dynamics and allosteric communication, revealing conformational changes and shifts in communication pathways.

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

This study shows that reducing Complex III in macrophages during viral infection dampens inflammation, improving recovery from H1N1 influenza.

This study identifies mRNA 3'-end processing protein complexes as interactors of DENV NS3 and shows their presence, not enzymatic activity, is critical for DENV replication.

This paper identifies evolutionarily conserved LRR proteins in velvet worm slime that form receptor-like structures, enabling reversible supramolecular network formation in bioadhesive fibers.

This paper develops an optogenetic tool to control PKC epsilon activity with spatiotemporal precision and validates its function in phosphorylation events.

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

This study shows that loss of IVNS1ABP causes a progeroid neuropathy by impairing proteostasis, leading to protein aggregation and lysosomal dysfunction in neuronal cells.

This study compares multi-omic profiles of bat and human fibroblasts, revealing differences in mitochondrial function and metabolic stress responses.

The paper identifies mTOR-mediated phosphorylation of LARP1 using a combined proteomics strategy and links it to nutrient responsiveness and dilated cardiomyopathy.