Author

Sher En Chan

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Crystal Jing Yi Lim· 2 shared Ler Ting Rachel LimiD· 2 shared Loo Chien WangiD· 2 shared Qunxiang OngiD· 2 shared Radoslaw Mikolaj SobotaiD· 2 shared Siok Ghee Ler· 2 shared Weiping HaniD· 2 shared Yilie LiaoiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Crystal Jing Yi Lim

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2 papers

Recent·Most cited

Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution

Qunxiang Ong, Crystal Jing Yi Lim, Yilie Liao, Justin Tze-Yang Ng, Ler Ting Rachel Lim, Shernys Xuan Yi Koh, Sher En Chan, P Lee, Hui-Jun Lim, Chen Ye, Loo Chien Wang, Siok Ghee Ler, Radoslaw Mikolaj Sobota, Yaw Sing Tan, Gerald I. Shulman, , Weiping Han

This paper develops an optogenetic tool to control PKC epsilon activity with spatiotemporal precision and validates its function in phosphorylation events.

bioRxiv · Jan 6, 2025 · PreprintMolecular Biology

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

Qunxiang Ong, Ler Ting Rachel Lim, Cameron Goh, Yilie Liao, Sher En Chan, Crystal Jing Yi Lim, Valerie Kam, Jerome Yap, Tiffany Tseng, Reina Desrouleaux, Loo Chien Wang, Siok Ghee Ler, Siew Lay Lim, Sun-Yee Kim, Radoslaw Mikolaj Sobota, , Xiaoyong Yang

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

Nature Chemical Biology · Nov 14, 2024Peer-reviewedCell Biology