Author

Cancan Lyu

University of Iowa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Songhai CheniD· 2 shared Ling YangiD· 1 shared Mark A. StamnesiD· 1 shared Sam Hall· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersCancer Biology

Songhai ChenORCID

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2 papers

Recent·Most cited

In vivo CRISPR screening links NFKB1 to endocrine resistance in ER⁺ breast cancer

Cancan Lyu, Sam Hall, Mark A. Stamnes, Songhai Chen

The paper identifies NFKB1 as a suppressor of endocrine resistance in ER⁺ breast cancer through in vivo CRISPR screening and shows that its loss activates NF-κB signaling, leading to resistance to endocrine therapy.

Endocrine Related Cancer · Sep 1, 2026Peer-reviewedCancer Biology

A Dual-Compartment Scaffolding Role for RACK1 in Hepatic Glucagon Signaling and Gluconeogenesis

Cancan Lyu, Ling Yang, Songhai Chen

This study identifies RACK1 as a dual-compartment scaffold that organizes the glucagon-PKA-CREB signaling axis to regulate hepatic gluconeogenesis.

bioRxiv · Jun 18, 2025 · PreprintPhysiology