Sam Hall

In vivo CRISPR screening links NFKB1 to endocrine resistance in ER⁺ breast cancer

The paper identifies NFKB1 as a suppressor of endocrine resistance in ER⁺ breast cancer through in vivo CRISPR screening and shows that its loss activates NF-κB signaling, leading to resistance to endocrine therapy.

Nitric oxide inhibits platelet adhesion to platelet-microparticles through reducing integrin αIIbβ3 activation

This study shows nitric oxide reduces PMP-induced platelet activation by inhibiting ADP release, TxA2 production, and integrin αIIbβ3 upregulation through cGMP-dependent signaling.