Songhai Chen

The paper identifies NFKB1 as a suppressor of endocrine resistance in ER⁺ breast cancer through in vivo CRISPR screening and shows that its loss activates NF-κB signaling, leading to resistance to endocrine therapy.

This study identifies RACK1 as a dual-compartment scaffold that organizes the glucagon-PKA-CREB signaling axis to regulate hepatic gluconeogenesis.

The paper shows that Glypican4 mediates Wnt transport between germ layers via signaling filopodia in zebrafish, rescuing convergence and extension defects.