Mark A. Stamnes

Survey of nucleotide-specific Rab GTPase interactions reveals multiple Rab effectors

The paper identifies nucleotide-specific interactions of Rab GTPases using yeast 2-hybrid and high-throughput sequencing, revealing new effector interactions and a novel Rab-binding domain.

In vivo CRISPR screening links NFKB1 to endocrine resistance in ER⁺ breast cancer

The paper identifies NFKB1 as a suppressor of endocrine resistance in ER⁺ breast cancer through in vivo CRISPR screening and shows that its loss activates NF-κB signaling, leading to resistance to endocrine therapy.

The HosA histone deacetylase regulates stress resistance, host cell interactions, and virulence in Aspergillus fumigatus

This study shows that HosA, a histone deacetylase in A. fumigatus, regulates stress resistance, host cell interactions, and virulence by modulating gene expression related to secondary metabolism and energy metabolism.

Loss of a conserved C-terminal region of the Aspergillus fumigatus AtrR transcriptional regulator leads to a gene-specific defect in target gene expression

The paper identifies a conserved C-terminal region in AtrR that is required for gene-specific activation of abcG1 and other membrane transporter genes but not cyp51A, revealing distinct mechanisms of AtrR-mediated transcription.

Transcription factor FfmA interacts both physically and genetically with AtrR to properly regulate gene expression in the fungus Aspergillus fumigatus

The paper investigates the interaction between transcription factors FfmA and AtrR in Aspergillus fumigatus, showing their physical and genetic interaction affects gene expression and azole resistance.

Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in Candida glabrata

This paper identifies Upc2A as a master regulator in Candida glabrata that coordinates sterol biosynthesis and membrane transporter production to mediate azole resistance.