Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex
Dustin R. Glasner, Candace Todd, B. Cook, Agustina D’Urso, Shivani Khosla, Elena Estrada, Jaxon D. Wagner, Mason D. Bartels, Pierce W. Ford, Jordan Prych, Kathryn S. Hatch, Brian A. Yee, Kaori M. Ego, Qishan Liang, Sarah R. Holland, , Matthew D. Daugherty
The paper shows that short 5' UTRs in viral mRNAs are recognized by the IFIT2-IFIT3 complex, leading to translation inhibition and antiviral activity.
bioRxiv · Feb 11, 2025 · PreprintMicrobiology