Load-dependent RGD-context sensing via αV-class integrins reprograms cellular adhesion and mechanics within seconds
Upnishad Sharma, Jakob M. Reber, Jonne H. Helenius, Cara Buchholz, Reinhard Faessler, Nico Strohmeyer, Daniel J. Müller
This study reveals how V-class integrins rapidly sense RGD motifs and reprogram cell adhesion and mechanics through distinct mechanotransduction pathways.
bioRxiv · Dec 12, 2025 · PreprintBiophysics