Carl A Anderson

Single-cell genetics identifies cell-type-specific effector genes across complex traits and diseases

The paper uses single-cell eQTL data to identify cell-type-specific effector genes associated with 69 diseases and 31 biomarker traits, revealing distinct immune cell contributions to disease.

Exploring the genetic architecture of inflammatory bowel disease by whole genome sequencing identifies association at ADCY7

This study uses whole genome sequencing to explore the genetic architecture of inflammatory bowel diseases, identifying a risk variant in ADCY7 for ulcerative colitis but finding limited contribution of low-frequency variants to heritability.

A protein truncating R179X variant in RNF186 confers protection against ulcerative colitis

The paper identifies a protein truncating variant in RNF186 that protects against ulcerative colitis by reducing disease risk.

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

This study identifies 26 new genetic loci associated with inflammatory bowel disease, including integrin genes linked to immune activation and disease risk.

Association mapping of inflammatory bowel disease loci to single variant resolution

This study fine-maps 94 inflammatory bowel disease loci to identify 45 causal variants with high confidence, providing insights into their functional impacts on disease mechanisms.