Luke Jostins

Genetic determinants of cytokine production in activated human monocytes

The paper identifies four genome-wide significant loci affecting monocyte cytokine release and links genetic variants to cytokine secretion patterns.

Bayesian meta-analysis across genome-wide association studies of diverse phenotypes

This paper introduces a Bayesian framework for meta-analyzing GWAS across diverse phenotypes, showing increased power compared to frequentist methods.

Genomic profiling of T cell activation reveals dependency of memory T cells on CD28 costimulation

Genomic profiling of CD4 T cell activation reveals a sensitivity switch from TCR in naive to CD28 in memory cells.

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

This paper develops a Bayesian framework to analyze genetic associations with healthcare phenotypes in the UK Biobank, identifying over 2,000 diagnostic term associations and novel immune-mediated disease links.

Exploring the genetic architecture of inflammatory bowel disease by whole genome sequencing identifies association at ADCY7

This study uses whole genome sequencing to explore the genetic architecture of inflammatory bowel diseases, identifying a risk variant in ADCY7 for ulcerative colitis but finding limited contribution of low-frequency variants to heritability.

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

This study identifies 26 new genetic loci associated with inflammatory bowel disease, including integrin genes linked to immune activation and disease risk.

Association mapping of inflammatory bowel disease loci to single variant resolution

This study fine-maps 94 inflammatory bowel disease loci to identify 45 causal variants with high confidence, providing insights into their functional impacts on disease mechanisms.