Relating GPCR domains with functionality: receptor helix-bundle and C-terminus differentially influence GRK-specific functions and β-arrestin-mediated regulation
Edda S. F. Matthees, Raphael Silvanus Haider, Laura Klement, Mona Reichel, Nina Kathleen Blum, Verena Weitzel, Thimea Trüpschuch, Carla Ziegler, Julia Drube, Stefan Schulz, Carsten Hoffmann
The paper investigates how GPCR domains influence β-arrestin functions and conformational changes, revealing domain-specific effects on signaling outcomes.
Journal of Pharmacology and Experimental Therapeutics · Mar 1, 2025Peer-reviewedPharmacology & Toxicology