Hematopoietic Stem And Progenitor Cells Use Podosomes To Transcellularly Home To The Bone Marrow.
Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber, Martijn A. Nolte, Carlijn Voermans, Jaap D. van Buul
This study shows that VE-cadherin regulates bone marrow vascular permeability and hematopoietic stem and progenitor cell (HSPC) homing, with HSPCs using podosomes to transcellularly enter the bone marrow.
bioRxiv · Feb 22, 2018 · PreprintCell Biology