Jaap D. van Buul

The paper shows that neutrophils use endothelial membrane tunnels for paracellular extravasation, formed by membrane lifting and indentation without requiring PECAM-1 or VE-cadherin.

This study shows that VE-cadherin RGD motifs are not essential for endothelial cell-cell junctions, barrier function, or leukocyte extravasation.

This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.

This study shows that VE-cadherin regulates bone marrow vascular permeability and hematopoietic stem and progenitor cell (HSPC) homing, with HSPCs using podosomes to transcellularly enter the bone marrow.