Leukocytes use endothelial membrane tunnels to extravasate the vasculature
Werner J. van der Meer, Abraham C.I. van Steen, Eike K. Mahlandt, Loïc Rolas, Haitao Wang, Janine J. G. Arts, Lanette Kempers, Max L.B. Grönloh, Rianne M. Schoon, Amber J. M. Driessen, Jos van Rijssel, Ingeborg Klaassen, Reinier O. Schlingemann, Yosif Manavski, Mark Hoogenboezem, , Jaap D. van Buul
The paper shows that neutrophils use endothelial membrane tunnels for paracellular extravasation, formed by membrane lifting and indentation without requiring PECAM-1 or VE-cadherin.
Cell Reports · Sep 1, 2025Peer-reviewedCell Biology