The loss of Tau in the adult brain triggers neuroplastic, epigenetic and behavioral deficits
Joana Margarida Silva, Shibojyoti Lahiri, Daniela Monteiro‐Fernandes, Carina Soares‐Cunha, Victor Solis‐Mezarino, Moritz Carl Völker-Albert, Georgia Papadimitrou, Patricia A. Gomes, Carlos Marques, Bárbara Coimbra, Inês Caetano Campos, Martina Samiotaki, George Panayotou, Nikolaos Kokras, Christina Dalla, , Ioannis Sotiropoulos
This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.
bioRxiv · Jan 23, 2026 · PreprintNeuroscience