Ioannis Sotiropoulos

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

This study shows that glucocorticoids promote vesicle-free Tau secretion and trans-neuronal Tau spreading in the brain, contributing to Alzheimer's disease progression.

This study identifies ATXN3's role in regulating neuronal mRNA splicing and Tau isoform ratio through deubiquitylation of splicing factors, linking it to SCA3 pathology.

This study shows Rab35 regulates APP and BACE1 trafficking to reduce Aβ production, and its downregulation by stress and aging contributes to amyloidogenesis.

The paper develops and validates a behavioral and EEG-based anesthesia scale for rodents, showing dose-dependent progression and reversal patterns.

This study shows that glucocorticoids impair Tau degradation via the Rab35/ESCRT pathway, leading to Tau accumulation and hippocampal dysfunction.