George Panayotou

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

The paper investigates how ERAP1 allotypes 2 and 10 affect the immunopeptidome of melanoma cells, finding quantitative changes in peptide abundance rather than sequence differences.

This study shows that ERAP1 inhibition alters the immunopeptidome and proteome in cancer cells, affecting metabolism and stress responses, but only a small fraction of proteomic changes impact the immunopeptidome.

This study shows that Puckered-mediated JNK signaling in pioneer neurons regulates VNC architecture and motor circuit coordination in Drosophila embryos.

The paper identifies a kinase inhibitor, BX795, that rescues pathological phenotypes in a patient-derived Parkinson's disease model through proteomic analysis and high-content screening.