This study uses mass spectrometry imaging and laser capture microdissection to analyze histone proteoforms in RTT mouse models, revealing neuron-specific differences and mutation-dependent chromatin changes.

FEBS Journal · Apr 1, 2026Peer-reviewedNeuroscience

Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins

Priyanka Bansal, Shibojyoti Lahiri, Chandni Natalia Kumar, Jessica Furtmeier, Lorenz Spechtenhauser, Lorenzo Galanti, Juan de Dios Barba Tena, Erika Chacin, Garp Linder, María Ángeles Ortiz-Bazán, Marisa Müller, Petra Vizjak, Tobias Straub, Felix Mueller‐Planitz, Johannes Stigler, , Christoph F. Kurat

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

Nature Communications · Mar 28, 2026Peer-reviewedBiochemistry

The loss of Tau in the adult brain triggers neuroplastic, epigenetic and behavioral deficits

Joana Margarida Silva, Shibojyoti Lahiri, Daniela Monteiro‐Fernandes, Carina Soares‐Cunha, Victor Solis‐Mezarino, Moritz Carl Völker-Albert, Georgia Papadimitrou, Patricia A. Gomes, Carlos Marques, Bárbara Coimbra, Inês Caetano Campos, Martina Samiotaki, George Panayotou, Nikolaos Kokras, Christina Dalla, , Ioannis Sotiropoulos

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

bioRxiv · Jan 23, 2026 · PreprintNeuroscience

Self-Reactive B Cells in Artery Tertiary Lymphoid Organs Encode Pathogenic High Affinity Autoantibody in Atherosclerosis

Chuankai Zhang, Xi Zhang, Yi Ran, Zhihua Wang, Liping Li, Shu Wang, Junjie Zheng, Yixin Zhang, Ting Sun, Yutao Li, Shu Lu, Mingyang Hong, Zhe Ma, Sabine Steffens, Michael Hristov, , Changjun Yin

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

bioRxiv · Jul 10, 2025 · PreprintImmunology