Caroline A. Obert

Deep Spatial Sequencing Revealing Differential Immune Responses in Human Hepatocellular Carcinoma

This study uses deep spatial sequencing to reveal differential immune responses in HCC and benign liver tissues, showing more intense HCC cell responses to immune cells.

The use of iconPCR for 16S library preparation improves data quality and workflow

The paper introduces iconPCR, a novel PCR technology that improves data quality and workflow by ensuring uniform amplification across reactions, leading to more accurate microbial community analysis.

Utility Analyses of AVITI Sequencing Chemistry

This study compares the AVITI and Illumina sequencing chemistries for DNA and RNA short-read and long-read sequencing, finding AVITI has higher quality scores and lower error rates in short-read applications.

Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells

The paper uses long-read single-cell sequencing to identify mutation-specific mRNA isoforms and fusion transcripts in liver cancer cells, improving classification of cancer versus benign cells.