Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation
Beata Niklas, Eléonore Moreau, Caroline Deshayes, Jakub Rydzewski, Milena Jankowska, Jacek Kęsy, Ademir Jesus Martins, Pie Mueller, Vincent Corbel, Wiesław Nowak, Bruno Lapied
This study shows that PBO inhibits cytochrome P450, reducing deltamethrin efficacy by altering Nav channel interactions through an octopamine-dependent pathway.
bioRxiv · Feb 3, 2025 · PreprintPharmacology & Toxicology