Author

Bruno Lapied

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementORCID 0000-0002-0354-4375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Beata NiklasiD· 2 shared Milena JankowskaiD· 2 shared Wiesław NowakiD· 2 shared Ademir Jesus MartinsiD· 1 shared Caroline Deshayes· 1 shared Eléonore MoreauiD· 1 shared Jacek KęsyiD· 1 shared Jakub RydzewskiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Beata NiklasORCID

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2 papers

Recent·Most cited

BiophysicsInternational Journal of Biological MacromoleculesPeer-reviewedNov 20, 2025

Evaluating the ligands' potency to modulate the fast inactivation of voltage-gated sodium channel.

Beata Niklas, Milena Jankowska, Katarzyna Walczewska-Szewc…·Wiesław Nowak

The paper uses steered molecular dynamics to evaluate ligands' ability to modulate fast inactivation of P. americana cockroach Nav channels, identifying PF-05089771 and PIP2 as inhibitors.

1 citation

biophysical modelingdrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintFeb 3, 2025

Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation

Beata Niklas, Eléonore Moreau, Caroline Deshayes…·Bruno Lapied

This study shows that PBO inhibits cytochrome P450, reducing deltamethrin efficacy by altering Nav channel interactions through an octopamine-dependent pathway.

DOI 10.1101/2025.02.03.636193

experimental assayhost-pathogen & immune response

𝕏 PostBluesky