Pharmacology & ToxicologybioRxivPreprint
Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation
Beata Niklas, Eléonore Moreau, Caroline Deshayes…·Bruno Lapied
This study shows that PBO inhibits cytochrome P450, reducing deltamethrin efficacy by altering Nav channel interactions through an octopamine-dependent pathway.
DOI 10.1101/2025.02.03.636193