Scott C. Baraban

The paper evaluates 4-PBA and its analogs for treating STXBP1 disorders using zebrafish models and finds no rescue of movement or seizure phenotypes.

This paper uses zebrafish to study SRGAP2 duplication, showing its role in microglia and visual system development, with phenotypes resembling human conditions.

This study evaluates how host brain age and region affect the survival, migration, and differentiation of transplanted MGE progenitors, finding that early postnatal transplantation yields better outcomes.

The paper tests nine putative antiseizure drugs in a scn1lab zebrafish model of Dravet syndrome, finding none significantly suppress seizures in electrophysiology assays.

The paper tests antiseizure drugs in a zebrafish model of STXBP1 disorder, finding clemizole and trazodone reduce seizure-like events by 80% and 83%.

This study describes xenotransplantation of porcine interneuron progenitor cells into the hippocampus of an epileptic California sea lion, resulting in seizure cessation and stabilized clinical measures.

This study shows that porcine embryonic medial ganglionic eminence progenitors develop into interneurons similar to rodents, supporting their use in xenotransplantation therapies.

The paper generates zebrafish models for 8 catastrophic childhood epilepsy genes and develops a classification scheme and open-source database for these models.

The paper identifies superhub cells in neural networks that, when targeted, more effectively stabilize epileptic networks compared to traditional hub cells.

The paper screens synthetic cannabinoids in a zebrafish model of Dravet Syndrome to identify anti-seizure compounds.