Dysfunctional memory B cell responses to the protective repeat region of the Plasmodium circumsporozoite protein are associated with waning humoral immunity
Courtney E McDougal, Catherine Mkindi, Lauren B. Rodda, Caroline V Lucarelli, Mark D. Langowski, Neil P. King, Said Abdallah Jongo, Claudia Daubenberger, Marion Pepper
The paper shows that the repetitive structure of the Plasmodium CSP protein affects B cell memory, leading to reduced humoral immunity over time.
bioRxiv · Sep 1, 2026 · PreprintImmunology