Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5
Matthew Williams, Xiaonan Wang, Hugo P. Bastos, Gabriela Grondys-Kotarba, Carys Johnson, Nicole Mende, Emily F Calderbank, Michelle Wantoch, Hyun Jung Park, Qin Wu, 金舒晟, Giovanna Mantica, Rebecca Hannah, Nicola K. Wilson, Dean C. Pask, , Anthony Richard Green
This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.
Blood Advances · Oct 7, 2024Peer-reviewedCell Biology