Anthony Richard Green

The paper identifies a JAK2-HNRNPA1 pathway that represses retrotransposon activity in haematopoietic stem cells, reducing insertional mutagenesis.

The paper analyzes paired tumor biopsies from Ewing sarcoma patients before and after pembrolizumab therapy to identify features of resistance to checkpoint inhibition.

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

The paper analyzes the mutational landscape of normal lymphocytes, revealing off-target effects of programmed genome engineering and the impact of differentiation and microenvironment exposure.

The paper identifies Notch signalling as essential for secondary senescence, distinguishing it from primary senescence through molecular endpoints.

This study investigates how TPO signaling rapidly remodels the epigenome in HSPCs by altering cis-regulatory activity and chromatin architecture.