Nicole Mende

The paper introduces an EPD assay to study human HSC lineage commitment and identifies IL-33 as a regulator of megakaryopoiesis by activating the MAPK pathway.

This study uses a cross-species bone marrow niche model to show that plasticity in the murine niche supports human HSC engraftment, highlighting its role in stem cell function.

Tripso, a self-supervised transformer model, identifies gene program-specific embeddings and discovers novel gene programs, revealing biological insights in hematopoietic development and disease.

PerturbGen predicts how genetic perturbations affect cellular trajectories across time in human datasets, showing effects on immune responses, hematopoiesis, and skin development.

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

The paper maps the multi-organ functions of the human yolk sac during early development, revealing its roles in hematopoiesis, nutrition, and oxygen regulation.

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.