Author

Casey Gonzales

The University of Texas Medical Branch at Galveston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Dario Villacreses· 3 shared Lynn SoongiD· 3 shared Yuejin LiangiD· 3 shared Hui Wang· 2 shared Emmett A. Dews· 1 shared Hema Prasad Narra· 1 shared Jiaren SuniD· 1 shared Joseph ThiriotiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

Dario Villacreses

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Selective Activation of Macrophage Innate Signaling Pathways and Inflammatory Responses to Orientia tsutsugamushi Karp and Gilliam Strains

Dario Villacreses, Casey Gonzales, Yuanyi Zhang, Yuejin Liang, Lynn Soong

This study compares immune responses to Orientia tsutsugamushi Karp and Gilliam strains in macrophages, identifying strain-specific transcriptional signatures and differential effects on inflammation and host resistance.

bioRxiv · Apr 26, 2026 · PreprintImmunology

A Humanized IFN-γ Mouse Model Reveals Skin Eschar Formation, Enhanced Susceptibility and Scrub Typhus Pathogenesis

Ryan Cho, Lihai Gao, Hui Wang, Yixuan Zhou, Casey Gonzales, Dario Villacreses, Emmett A. Dews, Xiaofei Zhou, Ruili Lv, Hema Prasad Narra, Lynn Soong, Yuejin Liang

This study develops a humanized IFN-γ mouse model that shows increased susceptibility to Orientia tsutsugamushi infection, skin eschar formation, and immune dysregulation, mimicking human scrub typhus pathogenesis.

PLoS Pathogens · Feb 11, 2026Peer-reviewedImmunology

Unique B Cell and Germinal Center Responses in Mice with Severe versus Mild Orientia tsutsugamushi Infection

Casey Gonzales, Yuejin Liang, Joseph Thiriot, Hui Wang, Dario Villacreses, Jiaren Sun, Lynn Soong

This study compares B cell and germinal center responses in mice infected with two Orientia tsutsugamushi strains, revealing distinct immune signatures associated with severe versus mild infection.

bioRxiv · Mar 27, 2025 · PreprintImmunology