Author

Yixuan Zhou

The University of Texas Medical Branch at GalvestonPrimary ORCID profile (0000-0002-5522-0671 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Yixuan ZhouiD2 papers · University of Chicago

Biology Disciplines

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Immunology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Hema Prasad Narra· 2 shared Hui Wang· 2 shared Lihai Gao· 2 shared Lynn SoongiD· 2 shared Ryan ChoiD· 2 shared Yuejin LiangiD· 2 shared Aubrey J. Osorio· 1 shared Carlos CepedaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Hema Prasad Narra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inducible nitric oxide synthase (iNOS) regulates skin eschar lesions, bacterial persistence, and inflammatory resolution in mouse models of scrub typhus

Yixuan Zhou, Lihai Gao, Ryan Cho, Judy Ly, Hui Wang, Hema Prasad Narra, Kun‐Hsien Tsai, Lynn Soong, Yuejin Liang

This study investigates the role of iNOS in regulating skin lesions, bacterial persistence, and inflammation resolution during scrub typhus in mice, showing its dual function in antimicrobial defense and inflammation control.

bioRxiv · Apr 20, 2026 · PreprintImmunology

A Humanized IFN-γ Mouse Model Reveals Skin Eschar Formation, Enhanced Susceptibility and Scrub Typhus Pathogenesis

Ryan Cho, Lihai Gao, Hui Wang, Yixuan Zhou, Casey Gonzales, Dario Villacreses, Emmett A. Dews, Xiaofei Zhou, Ruili Lv, Hema Prasad Narra, Lynn Soong, Yuejin Liang

This study develops a humanized IFN-γ mouse model that shows increased susceptibility to Orientia tsutsugamushi infection, skin eschar formation, and immune dysregulation, mimicking human scrub typhus pathogenesis.

PLoS Pathogens · Feb 11, 2026Peer-reviewedImmunology

Enhancer-targeted CRISPR-A rescues haploinsufficiency and mutant phenotypes in organoid models of autism

George T Chen, Gayatri Nair, Aubrey J. Osorio, Sandra M. Holley, Kimiya Ghassemzadeh, Yixuan Zhou, Jose Gonzalez, Jacqueline M. Martin, Congyi Lu, Neville E. Sanjana, Carlos Cepeda, Daniel H. Geschwind

This study uses CRISPR-A to enhance expression of CHD8 and SCN2A in organoids, rescuing haploinsufficiency and associated phenotypes in ASD models.

bioRxiv · Mar 13, 2024 · PreprintNeuroscience