Lynn Soong

This study compares immune responses to Orientia tsutsugamushi Karp and Gilliam strains in macrophages, identifying strain-specific transcriptional signatures and differential effects on inflammation and host resistance.

This study investigates the role of iNOS in regulating skin lesions, bacterial persistence, and inflammation resolution during scrub typhus in mice, showing its dual function in antimicrobial defense and inflammation control.

This study develops a humanized IFN-γ mouse model that shows increased susceptibility to Orientia tsutsugamushi infection, skin eschar formation, and immune dysregulation, mimicking human scrub typhus pathogenesis.

This study compares B cell and germinal center responses in mice infected with two Orientia tsutsugamushi strains, revealing distinct immune signatures associated with severe versus mild infection.

This study shows that lack of IFN-γ signaling leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions, highlighting its critical role in immune defense.