Translation fidelity mechanisms and their changes in aging
Mauricio Aguilar Rangel, Casey Powers, Jaeyoon Lee, Haley E. Tarbox, Neil B. Wood, Stephen D. Fried, Stephen R. Quake, Joseph Daniel Puglisi
This study measures proteome-wide translation errors in yeast and mouse, finding that fidelity varies by organism and tissue, increases with age in post-mitotic cells, and is regulated by tRNA pool remodeling.
bioRxiv · Sep 25, 2026 · PreprintMolecular Biology