Author

Haley E. Tarbox

Johns Hopkins UniversityORCID 0000-0002-8672-4792Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Stephen D. FriediD· 3 shared Anthony K. L. LeungiD· 1 shared Audrey BranchiD· 1 shared Casey Powers· 1 shared Charina S. FabilaneiD· 1 shared Hongrui LiuiD· 1 shared Jaeyoon LeeiD· 1 shared Jamie B. SpangleriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Stephen D. FriedORCID

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3 papers

Recent·Most cited

Translation fidelity mechanisms and their changes in aging

Mauricio Aguilar Rangel, Casey Powers, Jaeyoon Lee, Haley E. Tarbox, Neil B. Wood, Stephen D. Fried, Stephen R. Quake, Joseph Daniel Puglisi

This study measures proteome-wide translation errors in yeast and mouse, finding that fidelity varies by organism and tissue, increases with age in post-mitotic cells, and is regulated by tRNA pool remodeling.

bioRxiv · Sep 25, 2026 · PreprintMolecular Biology

Cognition-Associated Protein Structural Changes in a Rat Model of Aging are Related to Reduced Refolding Capacity

Haley E. Tarbox, Audrey Branch, Stephen D. Fried

The paper identifies cognition-associated structural changes in aged rat hippocampal proteins using LiP-MS and finds these proteins are less refoldable than non-CASC proteins.

Science Advances · Jul 11, 2025Peer-reviewedBiophysics

Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism

Hongrui Liu, Yuxuan Cai, Leilei Shi, Meenakshi Pillai, Nilimesh Das, Haley E. Tarbox, Yingda Ge, Kun Yue, Xingyi Yang, Piyush Rath, Mohsen Badiee, Charina S. Fabilane, Jamie B. Spangler, Mark T. Bedford, Sua Myong, , Anthony K. L. Leung

The paper shows PAR induces a conformational switch in FUS, enabling sustained condensation through N-terminal PrLD interactions after PAR degradation.

bioRxiv · Jul 3, 2025 · PreprintMolecular Biology