Jaeyoon Lee

This study measures proteome-wide translation errors in yeast and mouse, finding that fidelity varies by organism and tissue, increases with age in post-mitotic cells, and is regulated by tRNA pool remodeling.

The paper presents a single-cell long-read isoform atlas across 26 human tissues, revealing novel isoforms and their role in cellular identity and senescence.

This study identifies conserved and clade-specific hypothalamic cell types across vertebrates using single-cell transcriptomics, revealing conserved transcription factors and rewired regulatory linkages.

The paper expands Tabula Sapiens to include non-coding RNA data from 22 human tissues, revealing cell type-specific expression and subcellular localization patterns of non-coding RNAs.

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.