Engineering CAR-T cells to remodel the mucin-rich cancer cell glycocalyx
Sangwoo Park, Cassidy Ho, Alexandra N. Wolff, Yueyang Fan, Amanda A. Bouffard, Justin H. Paek, Adele Mucci, Trisha R. Berger, Matthew J. Paszek, Marcela Valderrama Maus
This study engineers CAR-T cells to secrete KLK5, a protease that remodels the mucin-rich glycocalyx, enhancing CAR-T cell function and tumor control in xenograft models.
bioRxiv · Sep 27, 2026 · PreprintBioengineering