Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10
Suparno Nandi, Sarah E. Strassler, Debayan Dey, Catherine B Whitney, Olivia B. Roumaya, Aiswarya Krishnamohan, George M Harris, Lindsay R. Comstock, Jane E. Jackman, Graeme L. Conn
This study determines the structural basis of Trm10's specific tRNA methylation by capturing its post-catalytic states using cryo-EM and MD simulations.
Nucleic Acids Research · Sep 4, 2026Peer-reviewedBiochemistry