Sarah E. Strassler

This study determines the structural basis of Trm10's specific tRNA methylation by capturing its post-catalytic states using cryo-EM and MD simulations.

The paper characterizes a missense mutation in EXOSC2 that affects the RNA exosome-Mtr4 interaction in yeast, showing functional consequences in RNA processing and drug sensitivity.

The paper creates a yeast model of SHRF mutations in EXOSC2 and compares it to an EXOSC3 mutation model, showing distinct RNA exosome functional impacts.