Jane E. Jackman

This study determines the structural basis of Trm10's specific tRNA methylation by capturing its post-catalytic states using cryo-EM and MD simulations.

This study compares Dictyostelium discoideum 3'-5' RNA polymerases, identifying a conserved residue with dual roles in catalysis and substrate specificity.

This study investigates the role of divalent metal ions in catalysis by 3'-5' RNA polymerases, revealing distinct metal dependencies and providing direct evidence of ATP and NTP presence in the active site.

This study explores the use of Thg1 and TLPs for targeted RNA synthesis at the 5-end using a templating RNA oligonucleotide, demonstrating their ability to incorporate up to 8 bases with high affinity.

The paper identifies a specific role for Trm10-mediated m1G9 modification in tRNATrp quality control in yeast, showing it is essential for tRNATrp function and subject to a distinct quality control mechanism.