Suparno Nandi

Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10

This study determines the structural basis of Trm10's specific tRNA methylation by capturing its post-catalytic states using cryo-EM and MD simulations.

KNexPHENIX: A PHENIX-Based Workflow for Improving Cryo-EM and Crystallographic Structural Models

KNexPHENIX improves structural models from cryo-EM and crystallography by refining them with better stereochemistry while maintaining model-to-map correlation and reducing overfitting.

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI

This study determines the cryo-EM structure of the RsmI-30S complex and reveals how RsmI recognizes and modifies the 16S rRNA C1402 nucleotide.

Distant Ribose 2'-O-Methylation of 23S rRNA Helix 69 Pre-Orders the Capreomycin Drug Binding Pocket at the Ribosome Subunit Interface