Extracellular Vesicle Carryover Distorts Nanoparticle Protein Corona Profiles in Human Plasma
Bahareh Ghaffari, Shaun Grumelot, Seyed Amirhossein Sadeghi, Alphan Alpaydin, Kylie Hilsen, Brooke Shango, Danilo Ritz, Alexander Schmidt, Hojatollah Vali, Liangliang Sun, Catherine J. Murphy, Amir Ata Saei, Babak Borhan, Morteza Mahmoudi
This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.
bioRxiv · Aug 3, 2026 · PreprintBioengineering