Author

Shaun Grumelot

Michigan State UniversityORCID 0009-0004-0357-1535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

Amir Ata SaeiiD· 2 shared Babak BorhaniD· 2 shared Brooke Shango· 2 shared Hojatollah ValiiD· 2 shared Kylie Hilsen· 2 shared Liangliang SuniD· 2 shared Morteza MahmoudiiD· 2 shared Seyed Amirhossein Sadeghi· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Amir Ata SaeiORCID

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2 papers

Recent·Most cited

Lipid nanoparticle protein coronas arise through lipoprotein fusion rather than shell-like adsorption

Shaun Grumelot, Naseeha Mohammed, Ghafar Yerima, Jorge A. Colón-Rosado, Seyed Amirhossein Sadeghi, Fei Fang, Kylie Hilsen, Brooke Shango, Amir Ata Saei, Amanda M. Murray, Michael J. Mitchell, Babak Borhan, Liangliang Sun, Hojatollah Vali, Mohammad R. K. Mofrad, , Morteza Mahmoudi

This study shows lipid nanoparticles form protein coronas through lipoprotein fusion, not surface adsorption, using cryo-EM and simulations.

Nano Letters · Aug 11, 2026Peer-reviewedBioengineering

Extracellular Vesicle Carryover Distorts Nanoparticle Protein Corona Profiles in Human Plasma

Bahareh Ghaffari, Shaun Grumelot, Seyed Amirhossein Sadeghi, Alphan Alpaydin, Kylie Hilsen, Brooke Shango, Danilo Ritz, Alexander Schmidt, Hojatollah Vali, Liangliang Sun, Catherine J. Murphy, Amir Ata Saei, Babak Borhan, Morteza Mahmoudi

This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.

bioRxiv · Aug 3, 2026 · PreprintBioengineering