Morteza Mahmoudi

Spatially precise neuron formation via hydrogel mediated modulation of the host astrocyte response

This paper develops a hydrogel-based system to reprogram astrocytes into neurons by delivering reprogramming factors and valproic acid, enhancing neural repair.

Lipid nanoparticle protein coronas arise through lipoprotein fusion rather than shell-like adsorption

This study shows lipid nanoparticles form protein coronas through lipoprotein fusion, not surface adsorption, using cryo-EM and simulations.

Extracellular Vesicle Carryover Distorts Nanoparticle Protein Corona Profiles in Human Plasma

This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.

Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer's disease

This paper identifies a stage-specific proteomic signature of Alzheimer's disease using plasma proteomics and finds a proteomic switch associated with disease progression.

Causality Analysis of Protein Corona Composition: Phosphatidylcholine-Enhances Plasma Proteome Profiling by Proteomics

This paper uses causality analysis to identify phosphatidylcholine as a key factor enhancing plasma proteome profiling through protein corona composition changes on nanoparticles.

Mass spectrometry-based top-down proteomics in nanomedicine: proteoform-specific measurement of protein corona

This study introduces a top-down proteomics method to precisely identify proteoforms in nanoparticle protein coronas, revealing biomarkers not detectable by bottom-up approaches.