Seyed Amirhossein Sadeghi

The paper introduces a visualization framework for top-down proteomics data, called proteoform barcode, which displays proteoform abundance and functional information, enabling disease diagnosis.

This study shows lipid nanoparticles form protein coronas through lipoprotein fusion, not surface adsorption, using cryo-EM and simulations.

This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

This study introduces a top-down proteomics method to precisely identify proteoforms in nanoparticle protein coronas, revealing biomarkers not detectable by bottom-up approaches.