Author

Babak Borhan

Michigan State UniversityORCID 0000-0002-3193-0732Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Amir Ata SaeiiD· 3 shared Morteza MahmoudiiD· 3 shared Alexander SchmidtiD· 2 shared Bahareh GhaffariiD· 2 shared Brooke Shango· 2 shared Danilo RitziD· 2 shared Hojatollah ValiiD· 2 shared Kylie Hilsen· 2 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Amir Ata SaeiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lipid nanoparticle protein coronas arise through lipoprotein fusion rather than shell-like adsorption

Shaun Grumelot, Naseeha Mohammed, Ghafar Yerima, Jorge A. Colón-Rosado, Seyed Amirhossein Sadeghi, Fei Fang, Kylie Hilsen, Brooke Shango, Amir Ata Saei, Amanda M. Murray, Michael J. Mitchell, Babak Borhan, Liangliang Sun, Hojatollah Vali, Mohammad R. K. Mofrad, , Morteza Mahmoudi

This study shows lipid nanoparticles form protein coronas through lipoprotein fusion, not surface adsorption, using cryo-EM and simulations.

Nano Letters · Aug 11, 2026Peer-reviewedBioengineering

Extracellular Vesicle Carryover Distorts Nanoparticle Protein Corona Profiles in Human Plasma

Bahareh Ghaffari, Shaun Grumelot, Seyed Amirhossein Sadeghi, Alphan Alpaydin, Kylie Hilsen, Brooke Shango, Danilo Ritz, Alexander Schmidt, Hojatollah Vali, Liangliang Sun, Catherine J. Murphy, Amir Ata Saei, Babak Borhan, Morteza Mahmoudi

This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.

bioRxiv · Aug 3, 2026 · PreprintBioengineering

Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer's disease

Negar Mahmoudi, Bahareh Ghaffari, Kenneth Rogale, Samuel Cheeseman, Danilo Ritz, Alexander Schmidt, Liuchenxin Han, Qingling Li, Jared S. Deyarmin, Stephanie N. Samra, Dmitry Leshchiner, Sachi Horibata, Christopher James Fowler, Borzoo Bonakdarpour, George Perry, , Morteza Mahmoudi

This paper identifies a stage-specific proteomic signature of Alzheimer's disease using plasma proteomics and finds a proteomic switch associated with disease progression.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience

Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis- Mediated Neurodegeneration

Morteza Sarparast, Elham Pourmand, Jennifer Hinman, Derek Vonarx, Tommy Reason, Fan Zhang, Shreya Paithankar, Bin Chen, Babak Borhan, Jennifer L. Watts, Jamie K. Alan, Kin Sing Stephen Lee

The paper identifies dihydroxyeicosadienoic acid as a metabolite of DGLA that induces ferroptosis-mediated neurodegeneration in dopaminergic neurons.

ACS Central Science · Mar 16, 2023Peer-reviewedNeuroscience