Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression
Alexandra T. Tankka, Jaclyn M. Einstein, Catherine J. Zhou, Vivian N. Pham, Yuhan Zhang, Jack T. Naritomi, Grady G. Nguyen, Orel Mizrahi, Mark Perelis, Joseph Sarsam, Frederick E. Tan, Dan S. Kaufman, Corina E. Antal, Gene Wei-Ming Yeo
The paper identifies PUF60's role in cancer progression by combining CRISPR screens and RNA-omics, showing its splicing activity supports TNBC proliferation and is a potential therapeutic target.
bioRxiv · May 1, 2025 · PreprintCancer Biology