Author

Mark Perelis

Ionis Pharmaceuticals (United States)ORCID 0000-0001-5435-2552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Gene Wei-Ming YeoiD· 2 shared Alexandra T. TankkaiD· 1 shared Ali R. NasiriiD· 1 shared Amit FulzeleiD· 1 shared Birgit KnebeliD· 1 shared Catherine J. Zhou· 1 shared Clara Bien PeekiD· 1 shared Corina E. AntaliD· 1 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMolecular Biology

Gene Wei-Ming YeoORCID

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4 papers

Recent·Most cited

Molecular BiologyRNAPeer-reviewedMay 29, 2025

Human CCR4 deadenylase homolog Angel1 is a Non-Stop mRNA Decay factor

Timothy Shaw, Megan E. Dowdle, Yasmeen Ajaj…·Jens Lykke‐Andersen

The paper identifies Angel1 as a key factor in non-stop mRNA decay by showing its role in destabilizing mRNAs lacking stop codons.

5 citations

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PathologyProceedings of the National Academy of SciencesPeer-reviewedMay 1, 2025

✦ In-depth digest

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

Ikki Sakuma, Rafael Calais Gaspar, Ali R. Nasiri…·Gerald I. Shulman

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.

46 citationstop 1%

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Cancer BiologybioRxivPreprintMay 1, 2025

Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression

Alexandra T. Tankka, Jaclyn M. Einstein, Catherine J. Zhou…·Gene Wei-Ming Yeo

The paper identifies PUF60's role in cancer progression by combining CRISPR screens and RNA-omics, showing its splicing activity supports TNBC proliferation and is a potential therapeutic target.

1 citation

humanbulk RNA-seq

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Molecular BiologyCurrent BiologyPeer-reviewedMay 30, 2019

Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

Luca Rizzini, Daniel C. Levine, Mark Perelis…·Michele Pagano

The paper shows mammalian Cryptochromes inhibit CRL4Cop1 complex assembly, similar to their function in plants, by interacting with Det1 to repress GR transcription.

24 citations

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